Excellent news for Allergy Therapeutics.  Allergy Therapeutics (AGY) Announces Positive Results From Grass Ph II Study. This company is interesting because AGY provides the only ultra-short course, aluminium-free treatment containing our MPL adjuvant in the European market. Further due to the dosing regimen it could be more convenient for patients. These factors AGY says is “driving market penetration in all our markets”.

Allergy Therapeutics announces positive top-line results from its Grass MATA MPL
Phase II dose ranging study

– Primary endpoint met with highly statistically significant dose-response relationship established

– Optimal -Phase III dose identified –

– Phase III study due to commence in 2019 

The science for this product makes sense and an important milestone for the company allowing it to step to the phase III trials.

AGY provide uses Grass Modified Allergen Tyrosine Absorbed (MATA) MPL and it’s aim was also to find a Phase II dose range which could then be used for the phase III work(G205).

The trial met its primary endpoint of establishing a dose-response relationship and a Phase III dose. 

 The key results announced today:

·      Primary endpoint of the trial met with highly statistically significant dose-response relationship (p<0.0001)  

·      All dosing regimens were safe and well tolerated

·      The currently marketed product showed a significant improvement compared to placebo (p<0.01)

·      Significant increase in immunoglobulin results, highly consistent with the dose response observed for the primary endpoint

·      Adherence to the short treatment course was excellent. More than 95% of patients received the target  cumulative dose during six weekly subcutaneous injections


The G205 trial is a multi-centre, double-blind, placebo controlled study designed to explore the safety and response of different cumulative doses of Grass MATA and MPL for grass-pollen induced seasonal allergic rhinitis. The European study took place in Germany, Poland and Austria and 447 patients were randomised into four active arms plus a placebo, evaluating the change in allergic symptoms as determined by the total symptom score (TSS) following conjunctival provocation test (CPT) with the objective to achieve a dose recommended for Phase III development.

Manuel Llobet, CEO at Allergy Therapeutics, stated that this success bring AGY closer towards marketing authorisation in the estimated $2bn US allergy market, a significant opportunity where our product has the potential to be the first registered subcutaneous immunotherapy for the treatment of grass allergy.

With an optimal dose identified, we look forward to sharing this new, exciting data with the health authorities and plan to commence a Phase III study in 2019. 


Making Smart Dubai Smarter

Seconds can be the difference between living, complications & death. Add to this clinical complexity, possibly a disease outbreak or a tower-block fire; any health-care system would be stretched to its limit. We strongly believe that the Acuity technology platform, with our globally trained medical experts, can facilitate clinicians to save lives”

Having arrived in Dubai in 2016, I realised the potential was immense to develop a health care system based on some neat IT infrastructure. Like in most advanced health care systems, I noted the issue of how best to to share healthcare assets share in a timeless and seamless way.

Reaching out to a Alumni at London Business School we started to work on a solution that could utilise Artificial Intelligence in decision making. Mr Waqas Mirza of Avanza and my London Business School colleague was willing to lend a hand.

For clinical emergencies, such as a heart attack, stroke or road traffic accident; seconds can be the difference between life and death. This is where Avanza’s Smart City Medical Management Platform “Acuity” will help to saves lives. Acuity is a Smart application for Smart Dubai, which will give the DHA perspective of what is happening across the city. Invaluable for Expo 2020 when the population of Dubai will burgeon from 3 million to 25 million over a 6-month period.

Lets take the emergency scenario once again. An urgent call is made to ambulance control and the ambulance is dispatched. As the ambulance is in on it’s way, Acuity, using Artificial Intelligence activates a series of complex decisions and messages to the medical network in the virtual nerve centre. This then leads to hospital activation, a hospital bed being reserved and even the appropriate medical team readied for imminent arrival of the patient. Acuity, then takes things a step further. Recognizing specific scenarios Acuity will be able to activate clinical teams. As such, the heart-attack victim would not waste time in the Emergency department and instead be whisked seamlessly into the cardiac suite to receive that life-saving stent.

Deploying such solutions that require multiple government agencies to work together would always be a challenge. Add to the mix of key private hospital partnerships, complexity just increased.

That is where the Dubai Future Accelerator program steps in … DFA is type of incubator allowing individuals and companies to bring great ideas and the ideas be sanctioned from the leadership down.

Avanza knew, to make Acuity Super-Smart, they needed to merge their knowledge of Block-Chain and Artificial Intelligence with the expertise of clinicians and emergency care specialists. In a unique collaboration with internationally trained health care professionals, Avanza is aiming to achieve the holy-grail – right patient at the right location with the right clinician. To make Acuity smarter and capable of responding to the regional nuisances, Acuity will store data and use it to design better algorithms based on concepts of machine learning. Additionally, Acuity allows the DHA and hospital-based healthcare professionals to be able to view data pertaining to specific patients, as the data is being entered by the Ambulance crew. Thereby, vital observations are shared on the Acuity platform so that any number of doctors can discuss the case, with chat being possible within Acuity in real-time.

The ultimate aim for Acuity is to match supply of critical medical facilities and equipment with real-time demand of emergency cases. In the future, Acuity could even predict health-care demand and in-doing so, the DHA could fore plan using Dubai’s network of private and public hospital’s. This would ensure healthcare delivery is optimized and demand never outstrips supply. Further as Acuity gains traction smart IOT architecture can further provide vital synergies allowing the Acuity nerve centre to react and respond in ways one could never fathom. For example, knowing at the exact time a bed is vacated by a patient or when a specifically trained doctor enters the building and is required for an emergency for a patient that is en-route.

Globally, large-scale events, be it natural or man-made, have stretched medical systems and placed undue strain on cities and their citizens. In this regard, Acuity has a central preparatory role, allowing Dubai to be protected under a shroud of technological efficiency. Avanza, through Acuity, facilitates healthcare professionals, allowing the Dubai Health Authority to delivery on its mandate to preserve and protect the people of Dubai.

Lets make Smart Dubai ….. Smarter

MBA for Executives …. life changing or no?

Perhaps like me, many executives interested in advancing their career are faced with the same question …. should one consider further higher training and at what cost? Does an MBA bring the required reward? So in your analysis you see the glossy brochures and you do the web-research and it all looks good… no? Many ROI calculations later, the answer still may not seem any clearer.

Like many Alumni I was very proud of London Business School’s recent Achievement as the number one program for Executives fourth year running. What has this accilade meant for me?

2011 …. having reached the top of my career in Medicine … I faced that question faced by many executives…. what’s next ? Its usual in other career lines to think about an MBA at the start or mid career… for Doctors the road is not as well travelled.

So let me share my story some 4 years after completing the London Business School Executive MBA Program. Where did this decision lead me?

A key aspect of the London Business School program is that it is part-time, so executives can lead continue work whilst partaking in the program. Which is what I did, travelling to London was much easier for me, being based in the Midlands at the time. Unlike some students who caught regular flights to make it to class.

An advantage of the LBS MBA is that it provides a dual-site program. One Executive class was made of two groups, one based in Dubai and one in London. There was regular mixing of the groups with the convenience afforded by the program to allow executives within the region to be based in proximity to their work. So the London Campus with in Regent’s Park and the Dubai Campus at Dubai International Financial Centre. As a result attendees from afar, for example, from South Korea and Africa could partake in the executive program whilst continuing their work.

An important question for me, when choosing the MBA program was whether to stay niche and aim for a Medical MBA program (not offered at LBS). The advantage of undertaking a generic MBA program rather than one based around one field is that is allowed me to forge partnerships with people outside my field. This was especially important when I wanted to approach the Dubai Government with a Health Care innovation based around programming and Artificial Intelligence.

It is the edge of boundaries of separate disciplines, when the boundaries overlap sparks ideas and moves branches forward.

Nothing will happen if you are a passive bystander hoping for opportunities with or without a MBA. For the new entrant to a field the MBA provides the tools for the future. For the executive MBA entrant rubbing shoulders with similar executives is a serious advantage one should be ready to avail onself to. So, it is up to you at business school to develop your network and to develop the friendships that could one day be mutually beneficial for ones future direction.

I always tell prospective students, one can accumulate educational material and try to learn MBA concepts without paying hefty fees. However it is the discussion the MBA program brings that is the added value of a tier one MBA school. The opportunity thus afforded works on one’s capabilities affecting managerial and leadership qualities.

My move to the Middle East and in particular to Dubai was galvanised as a result of my exposure in the MBA program to Dubai classmates. Also attending classes at the LBS hub at DIFC Dubai allowed me an experience that inspired me to the next step. This then forged the relationship with colleagues such as Waqas Mirza, director at Avanza solutions. You can read more anout this collaboration in my other post.

One important piece of advice for the exec MBA … don’t expect a life change straight after your program … instead envisage that this will happen in at least two steps if not more. Whilst undertaking the porgram, I was appointed on board of Non-Executive Boards in the UK NHS CCG. The MBA program was key to these appointments.

The career support provided by the school is very important if you are interseted in gaining the necessary networks allowing you to move sideways or upwards. For the London Business School program the strength of the executive career program was in finance and banking. As the scope of the backgrounds of the Executive MBA’s becomes more widespread at the school then the Career program will have to adjust accordingly.

An immediate area of benefit of the Executive MBA was to the Volunteer work I provide for a charity running a Not for Profit NGO in North Pakistan … Midland Doctors. I achieved a distinction in Marketing in the MBA program and this I used applying to the areas of marketing strategy and digitial entreprenuership. The hospital , which I help to manage on a charitable basis, is therefore also a postive recipient of the life skills I have attained at London Business School

Dubai to get a highly advanced medical nerve centre

Taking the step from idea to innovation requires clarity, focus and dedication. There are many moving parts including the multiple stakeholders involved in managing the same.

I have lectured on medical innovation and emphasised the need to understand entrepreneurship in making the idea come to fruition. An important step is understanding the end-user and the clinical advantages of the solution.